Calibrate your way using KIN-TEK Trace Source™ Permeation Tube technology combined with KIN-TEK’s EcoFlex™ Standalone gas standard system, 491Flex™ manually operated expandable system, or KIN-TEK’s fully automated and expandable FlexStream™ System.

• Accurate sub-ppm to pptr gas concentrations for calibrating GC, GC-MS, or other devices.
• Multiple gases and a multipoint calibration curve generated using  Trace Source™ Permeation Tubes in a KIN-TEK Gas Standard Generator.
• 550+ NIST-traceable gas compounds available to provide complex gas mixtures.

KIN-TEK introduces the FlexMixer™ Multi-Gas Blending/Diluting System that mixes or dilutes up to 4 separate gas feeds (or cylinder sources) to one Span Gas output. Click here for more information about the FlexMixer™

Modular configurations provide interchangeable and expandable calibration scenarios giving you full control to Calibrate Your Way!

Calibration challenges solved with Permeation Tube Technology

Challenge: The challenge is that permanent gases or air pollutants that cannot be liquefied, such as O2, NO, CO, N2, CH4, NO, etc. must be used in the gas form for calibration and are unstable in static mixtures at trace concentrations (ppm and lower). Using a permeation tube emitting at a very low flow rate for dilution to ppm and lower concentrations requires precision flow, pressure, and temperature control devices. Dynamically generating the gas mixture as it is needed eliminates issues created from storing the mixture.

Solution: Trace Source™ 57H Gas Fed permeation tubes used within a system that combines the FlexStream™ Base and PM/GF Modules provide the controls needed for creating trace concentrations of high vapor pressure (permanent) gases such as O2, NO, CO, N2, CH4, etc. that cannot be liquefied. The mechanism and controls needed to deliver accurate gas standards at trace concentrations is a combination of the tube construction and the equipment controls required to hold the tube at equilibrium conditions.  The FlexStream™ System provides automated mechanical controls to hold the permeation tube at equilibrium for dynamically delivering a precise gas standard with each use.

Read more  “Low Concentration Calibration for High Vapor Pressure Gases”

Why Trace Gas Concentrations are important for Disease Diagnosis…

Challenge: A breath analysis medical technology that is a quick and non-invasive test for detecting diseases is currently being developed using trace gas concentrations as biomarkers. Fluctuations in gas concentrations of various metabolic gases can determine if a person is healthy, at risk, or sick.  For example, measuring Hydrocarbons, aromatic compounds, Nitriles, and Ketones in human breath can diagnose lung cancer but precise quantities of test gases are required to aid in biomarker research.

Referencing the linked papers below, trace concentrations of Heptane and Isopentane vapor were generated to test measurement values for establishing biomarkers related to lung cancer. Both papers determine if a breath analyzing technique is effective in analyzing different concentration ranges needed for effective and accurate  diagnosis.

Other research includes the analysis of trace Ammonia for Chronic Kidney Disease (CKD), Ethane and Acetone for Diabetes, and Carbonyl Sulfide for Liver Disease. Simulating trace gases expelled from patients fordetermining disease requires accurate and precise gas standards targeting ppm, ppb, and pptr concentrations that are not easily provided using a static cylinder blend.

Target ppm and lower gas concentrations…

Solution: KIN-TEK offers the modular and automated FlexStream™ system that can target ppm and lower gas concentrations of over 550 different gas standards. The FlexStream™ system can create ppm down to pptr concentrations with a Base Module and Secondary Dilution Module. Each permeation tube in this system has a dilution range of 1:10,000. This allows a researcher to create a wide range of compounds and concentrations for gas standards.

With accuracy and reliability being key factors, the FlexStream™ system with Trace Source™ permeation tubes offers always fresh NIST traceable concentrations. With the complimentary FlexLink™ software that comes with the FlexStream™, data can be logged over time and saved to the computer for reference.

Published Papers Using KIN-TEK Products:

ZEUS (ZIF-based electrochemical ultrasensitive screening) device for isopentane analytics with focus on lung cancer diagnosis

R.E.A.C.T-Rapid Electro-Analytical graphitic Carbon nitride-based screening Tool for lung cancer – Case study using heptane